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CHLOROPHENYL GABA
Descriptors Found:
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DeCS
Descriptor
English
:
Baclofen
Descriptor
Spanish
:
Baclofeno
Descriptor
Portuguese
:
Baclofeno
Synonyms
English
:
Baclophen
Chlorophenyl GABA
Tree Number:
D02.241.081.114.500.350.100
Definition
English
:
A
GAMMA-AMINOBUTYRIC ACID
derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of
MUSCLE SPASTICITY
, especially that due to
SPINAL CORD INJURIES
. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
Pharmacological Action:
GABA-B Receptor Agonists
Muscle Relaxants, Central
History Note
English
:
80(75); was see under AMINOBUTYRIC ACIDS 1975-79
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
1442
Unique Identifier:
D001418
Occurrence in VHL
:
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DeCS
CID-10
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